| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AQR |
| Gene ID: | 9716 |
| Uniprot ID: | AQR_HUMAN |
| Immunogen Region: | 400-700 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human AQR (NP_055506.1). |
| Immunogen Sequence: | KEFLLELLVSRHERRISQIQ QLNQMPLYPTEKIIWDENIV PTEYYSGEGCLALPKLNLQF LTLHDYLLRNFNLFRLESTY EIRQDIEDSVSRMKPWQSEY GGVVFGGWARMAQPIVAFTV VEVAKPNIGENWPTRVRADV TINLNVRDHIKDEWEGLRKH DVCFLITVRPTKPYGTKFDR RRPFIEQVGLVYVRGCEIQG MLDDKGRVIEDGPEPRPNLR GESRTFRVFLDPNQYQQDM |
| Function | Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro). |
| Protein Name | Rna Helicase AquariusIntron-Binding Protein Of 160 KdaIbp160 |
| Database Links | Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleoplasmLocalizes To Speckle-Like Regions Of The Nucleoplasm |
| Alternative Antibody Names | Anti-Rna Helicase Aquarius antibodyAnti-Intron-Binding Protein Of 160 Kda antibodyAnti-Ibp160 antibodyAnti-AQR antibodyAnti-KIAA0560 antibody |
Information sourced from Uniprot.org