| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-AQR (1250-1300) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.57-0.60 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:250 IHC: 1:50-1:250 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | AQR |
| Gene ID: | 9716 |
| Uniprot ID: | AQR_HUMAN |
| Immunogen Region: | 1250-1300 |
| Immunogen: | Synthetic peptide taken within amino acid region 1250-1300 on human RNA helicase aquarius protein. |
| Function | Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro). |
| Protein Name | Rna Helicase Aquarius Intron-Binding Protein Of 160 Kda Ibp160 |
| Database Links | Reactome: R-HSA-6781823 Reactome: R-HSA-6781827 Reactome: R-HSA-6782135 Reactome: R-HSA-6782210 Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus Nucleoplasm Localizes To Speckle-Like Regions Of The Nucleoplasm |
| Alternative Antibody Names | Anti-Rna Helicase Aquarius antibody Anti-Intron-Binding Protein Of 160 Kda antibody Anti-Ibp160 antibody Anti-AQR antibody Anti-KIAA0560 antibody |
Information sourced from Uniprot.org