| Short Description : | Rabbit polyclonal AQP5 (188-203) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:5000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AQP5 |
| Gene ID: | 362 |
| Uniprot ID: | AQP5_HUMAN |
| Immunogen Region: | 188-203 |
| Immunogen Sequence: | GLSVTLGHLVGIYFTGCSMN PARSFGPAVVMNRFSPAHWV FWVGPIVGAVLAAILYFYLL FPNSLSLSERVAIIKGTYEP DEDWEEQREERKKTMELTTR |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 166-265 of human AQP5 (NP_001642.1). |
| Tissue Specificity | Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level). |
| Function | Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands. |
| Protein Name | Aquaporin-5Aqp-5 |
| Database Links | Reactome: R-HSA-432047 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle MembraneHypotonicity Increases Location At The Cell MembranePhosphorylation Decreases Location At The Cell Membrane |
| Alternative Antibody Names | Anti-Aquaporin-5 antibodyAnti-Aqp-5 antibodyAnti-AQP5 antibody |
Information sourced from Uniprot.org
