| Post Translational Modifications | O-glycosylation.glycosaminoglycan of chondroitin-sulfate type. |
| Function | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. |
| Protein Name | Micos Complex Subunit Mic26Apolipoprotein OMicos Complex Subunit Mic23Protein Fam121b |
| Database Links | Reactome: R-HSA-8949613 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane ProteinSecretedMitochondrionGolgi Apparatus MembraneEndoplasmic Reticulum MembraneExists In Three Distinct Forms: A Glycosylated And Secreted FormAn Er/Golgi-Resident Form And A Non-Glycosylated Mitochondrial Form |
| Alternative Antibody Names | Anti-Micos Complex Subunit Mic26 antibodyAnti-Apolipoprotein O antibodyAnti-Micos Complex Subunit Mic23 antibodyAnti-Protein Fam121b antibodyAnti-APOO antibodyAnti-FAM121B antibodyAnti-MIC23 antibodyAnti-MIC26 antibodyAnti-My025 antibodyAnti-UNQ1866 antibodyAnti-PRO4302 antibody |
Information sourced from Uniprot.org
