Post Translational Modifications | (Microbial infection) Following infection by some HIV-1 strains, such as isolate BRU/LAI, can be ubiquitinated by a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, leading to its degradation. Ubiquitination by the ECS complex is however less efficent compared to APOBEC3G or APOBEC3G. |
Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. |
Protein Name | Dna Dc->Du-Editing Enzyme Apobec-3hApobec-Related Protein 10Arp-10Apolipoprotein B Mrna-Editing Enzyme Catalytic Polypeptide-Like 3hA3h |
Database Links | Reactome: R-HSA-72200Reactome: R-HSA-75094 |
Cellular Localisation | CytoplasmNucleusP-BodyHaplotype 1 Is Distributed In Both The Nucleus And CytoplasmWhereas Haplotype 2 Is Predominantly Cytoplasmic |
Alternative Antibody Names | Anti-Dna Dc->Du-Editing Enzyme Apobec-3h antibodyAnti-Apobec-Related Protein 10 antibodyAnti-Arp-10 antibodyAnti-Apolipoprotein B Mrna-Editing Enzyme Catalytic Polypeptide-Like 3h antibodyAnti-A3h antibodyAnti-APOBEC3H antibody |
Information sourced from Uniprot.org