| Post Translational Modifications | (Microbial infection) Following infection by HIV-1, ubiquitinated by a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, leading to its degradation. Deubiquitinated by USP49.leading to stabilization. Phosphorylation at Thr-32 reduces its binding to HIV-1 Vif and subsequent ubiquitination and degradation thus promoting its antiviral activity. |
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons. |
| Protein Name | Dna Dc->Du-Editing Enzyme Apobec-3gApobec-Related Cytidine DeaminaseApobec-Related ProteinArcdApobec-Related Protein 9Arp-9Cem-15Cem15Deoxycytidine DeaminaseA3g |
| Database Links | Reactome: R-HSA-180585Reactome: R-HSA-180689 |
| Cellular Localisation | CytoplasmNucleusP-BodyMainly CytoplasmicSmall Amount Are Found In The NucleusDuring Hiv-1 InfectionVirion-Encapsidated In Absence Of Hiv-1 Vif |
| Alternative Antibody Names | Anti-Dna Dc->Du-Editing Enzyme Apobec-3g antibodyAnti-Apobec-Related Cytidine Deaminase antibodyAnti-Apobec-Related Protein antibodyAnti-Arcd antibodyAnti-Apobec-Related Protein 9 antibodyAnti-Arp-9 antibodyAnti-Cem-15 antibodyAnti-Cem15 antibodyAnti-Deoxycytidine Deaminase antibodyAnti-A3g antibodyAnti-APOBEC3G antibodyAnti-MDS019 antibody |
Information sourced from Uniprot.org
