Anti-APOBEC3B antibody (120-220 aa) [S5040RM] (STJ11105040)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Dna Dc->Du-Editing Enzyme Apobec-3b (120-220 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5040RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APOBEC3B |
| Gene ID | 9582 |
| Uniprot ID | ABC3B_HUMAN |
| Immunogen Region | 120-220 aa |
| Immunogen Sequence | AARLYYYWERDYRRALCRLS QAGARVTIMDYEEFAYCWEN FVYNEGQQFMPWYKFDENYA FLHRTLKEILRYLMDPDTFT FNFNNDPLVLRRRQTYLCYE V |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 120-220 of human APOBEC3B. (NP_004891.5). |
Additional Info
| Tissue Specificity | Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues. |
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. |
| Protein Name | Dna Dc->Du-Editing Enzyme Apobec-3bA3bPhorbolin-1-Related ProteinPhorbolin-2/3 |
| Database Links | Reactome: R-HSA-72200Reactome: R-HSA-75094 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna Dc->Du-Editing Enzyme Apobec-3b antibodyAnti-A3b antibodyAnti-Phorbolin-1-Related Protein antibodyAnti-Phorbolin-2/3 antibodyAnti-APOBEC3B antibody |
Information sourced from Uniprot.org