Anti-APLP2 antibody (370-580) (STJ27408)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal APLP2 (370-580) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APLP2 |
| Gene ID | 334 |
| Uniprot ID | APLP2_HUMAN |
| Immunogen Region | 370-580 |
| Immunogen Sequence | PTNDVDVYFETSADDNEHAR FQKAKEQLEIRHRNRMDRVK KEWEEAELQAKNLPKAERQT LIQHFQAMVKALEKEAASEK QQLVETHLARVEAMLNDRRR MALENYLAALQSDPPRPHRI LQALRRYVRAENKDRLHTIR HYQHVLAVDPEKAAQMKSQV MTHLHVIEERRNQSLSLLYK VPYVAQEIQEEIDELLQEQR ADMDQFTASIS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 370-580 of human APLP2 (NP_001633.1). |
Additional Info
| Tissue Specificity | Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues. |
| Post Translational Modifications | The BPTI/Kunitz inhibitor domain is O-glycosylated. |
| Function | May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts. |
| Protein Name | Amyloid Beta Precursor Like Protein 2ApphAmyloid BetaA4 Precursor-Like Protein 2Amyloid Protein HomologAmyloid-Like Protein 2Aplp-2Cdei Box-Binding ProteinCdebpSperm Membrane Protein Ywk-Ii |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinNucleus |
| Alternative Antibody Names | Anti-Amyloid Beta Precursor Like Protein 2 antibodyAnti-Apph antibodyAnti-Amyloid Beta antibodyAnti-A4 Precursor-Like Protein 2 antibodyAnti-Amyloid Protein Homolog antibodyAnti-Amyloid-Like Protein 2 antibodyAnti-Aplp-2 antibodyAnti-Cdei Box-Binding Protein antibodyAnti-Cdebp antibodyAnti-Sperm Membrane Protein Ywk-Ii antibodyAnti-APLP2 antibodyAnti-APPL2 antibody |
Information sourced from Uniprot.org