Anti-APLNR nanobody [SAA1115] (STJN000208)

Anti-APLNR nanobody [SAA1115] (STJN000208)

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STJN000208
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Covered by St John's Laboratory Guarantee

Host: Alpaca
Applications: Agonist/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Apelin Receptor is suitable for use in Agonist and ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1115
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: APLNR
Gene ID: 187
Uniprot ID: APJ_HUMAN
Function Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.may be involved in the development of AIDS dementia.
Protein Name Apelin Receptor
Angiotensin Receptor-Like 1
G-Protein Coupled Receptor Apj
G-Protein Coupled Receptor Hg11
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
After Exposure To Apelin (Apln)
Internalized From The Cell Surface Into An Endosomal Recycling Compartment
From Where It Is Recycled To The Cell Membrane
After Exposure To Apelin Receptor Early Endogenous Ligand (Apela)
Alternative Nanobody Names Anti-Apelin Receptor nanobody
Anti-Angiotensin Receptor-Like 1 nanobody
Anti-G-Protein Coupled Receptor Apj nanobody
Anti-G-Protein Coupled Receptor Hg11 nanobody
Anti-APLNR nanobody
Anti-AGTRL1 nanobody
Anti-APJ nanobody

Information sourced from Uniprot.org

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