| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | APLNR |
| Gene ID: | 187 |
| Uniprot ID: | APJ_HUMAN |
| Immunogen Region: | 301-380 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 301-380 of human APLNR (NP_005152.1). |
| Immunogen Sequence: | NSCLNPFLYAFFDPRFRQAC TSMLCCGQSRCAGTSHSSSG EKSASYSSGHSQGPGPNMGK GGEQMHEKSIPYSQETLVVD |
| Tissue Specificity | Expressed in heart, brain, kidney, stomach, spleen, thymus, lung, ovary, small intestine and colon, adipose tissues and pancreas. Expressed in glial cells, astrocytes and neuronal subpopulations. Expressed in embryonic (ESCs) and induced (iPSCs) pluripotent stem cells. |
| Function | Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.may be involved in the development of AIDS dementia. |
| Protein Name | Apelin Receptor Angiotensin Receptor-Like 1 G-Protein Coupled Receptor Apj G-Protein Coupled Receptor Hg11 |
| Database Links | Reactome: R-HSA-375276 Reactome: R-HSA-418594 |
| Cellular Localisation | Cell Membrane After Exposure To Apelin (Apln) Internalized From The Cell Surface Into An Endosomal Recycling Compartment From Where It Is Recycled To The Cell Membrane After Exposure To Apelin Receptor Early Endogenous Ligand (Apela) |
| Alternative Antibody Names | Anti-Apelin Receptor antibody Anti-Angiotensin Receptor-Like 1 antibody Anti-G-Protein Coupled Receptor Apj antibody Anti-G-Protein Coupled Receptor Hg11 antibody Anti-APLNR antibody Anti-AGTRL1 antibody Anti-APJ antibody |
Information sourced from Uniprot.org