• Immunohistochemistry of rat small intestine with Anti-APLN primary antibody (STJ500102) at 1:50 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-APLN antibody (25-77) (STJ500102)

SKU:
STJ500102-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-APLN (25-77) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:50, 000
IP: 1:200
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: APLN
Gene ID: 8862
Uniprot ID: APEL_HUMAN
Immunogen Region: 25-77
Immunogen: Synthetic peptide taken within amino acid region 25-77 on human Apelin protein.
Tissue Specificity Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk.
Post Translational Modifications Several active peptides may be produced by proteolytic processing of the peptide precursor.
Function Endogenous ligand for the apelin receptor (APLNR). Drives internalization of the apelin receptor. Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR. Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking.the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior. (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives.
Protein Name Apelin
Apj Endogenous Ligand Cleaved Into - Apelin-36 - Apelin-31 - Apelin-28 - Apelin-13
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-418594
Cellular Localisation Secreted
Extracellular Space
Abundantly Secreted In The Colostrum
Lower Level In Milk
Decreases Rapidly Within Several Days After Parturition In Milk
But Is Still Detectable Even In Commercial Milk
Alternative Antibody Names Anti-Apelin antibody
Anti-Apj Endogenous Ligand Cleaved Into - Apelin-36 - Apelin-31 - Apelin-28 - Apelin-13 antibody
Anti-APLN antibody
Anti-APEL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance