| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-APITD1 (1-138) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CENPS |
| Gene ID: |
100526739/378708 |
| Uniprot ID: |
CENPS_HUMAN |
| Immunogen Region: |
1-138 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human APITD1 (NP_954988.1). |
| Immunogen Sequence: |
MEEEAETEEQQRFSYQQRLK AAVHYTVGCLCEEVALDKEM QFSKQTIAAISELTFRQCEN FAKDLEMFARHAKRTTINTE DVKLLARRSNSLLKYITDKS EEIAQINLERKAQKKKKSED GSKNSRQPAEAGVVESEN |
| Tissue Specificity | Ubiquitously expressed. |
| Function | DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own. |
| Protein Name | Centromere Protein SCenp-SApoptosis-Inducing Taf9-Like Domain-Containing Protein 1Fancm-Associated Histone Fold Protein 1Fancm-Interacting Histone Fold Protein 1Fanconi Anemia-Associated Polypeptide Of 16 Kda |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-6783310Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreAssembly Of Cenps And Cenpx And Its Partner Subunits Cenpt And Cenpw At Centromeres Occurs Through A Dynamic Exchange MechanismAlthough Exchange Is Continuous In The Cell CycleDe Novo Assembly Starts Principally During Mid-Late S Phase And Is Complete By G2Cenps Is More Stably Bound At The Kinetochore Than CenpxDuring S PhaseRapidly Recruited To Dna Interstrand Cross-Links That Block ReplicationRecruited To Dna Damage Sites About 20 Minutes Following Uv IrradiationReaching A Plateau After Approximately 40 Minutes |
| Alternative Antibody Names | Anti-Centromere Protein S antibodyAnti-Cenp-S antibodyAnti-Apoptosis-Inducing Taf9-Like Domain-Containing Protein 1 antibodyAnti-Fancm-Associated Histone Fold Protein 1 antibodyAnti-Fancm-Interacting Histone Fold Protein 1 antibodyAnti-Fanconi Anemia-Associated Polypeptide Of 16 Kda antibodyAnti-CENPS antibodyAnti-APITD1 antibodyAnti-FAAP16 antibodyAnti-MHF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
