| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Apoptosis inhibitor 5 (421-470 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | API5 |
| Gene ID: | 8539 |
| Uniprot ID: | API5_HUMAN |
| Immunogen Region: | 421-470 aa |
| Specificity: | API5 Polyclonal Antibody detects endogenous levels of API5 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human API-5 at the amino acid range 421-470 |
| Post Translational Modifications | Acetylation at Lys-251 impairs antiapoptotic function. |
| Function | Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. |
| Protein Name | Apoptosis Inhibitor 5Api-5Antiapoptosis Clone 11 ProteinAac-11Cell Migration-Inducing Gene 8 ProteinFibroblast Growth Factor 2-Interacting FactorFifProtein Xagl |
| Cellular Localisation | NucleusCytoplasmMainly NuclearCan Also Be CytoplasmicIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Apoptosis Inhibitor 5 antibodyAnti-Api-5 antibodyAnti-Antiapoptosis Clone 11 Protein antibodyAnti-Aac-11 antibodyAnti-Cell Migration-Inducing Gene 8 Protein antibodyAnti-Fibroblast Growth Factor 2-Interacting Factor antibodyAnti-Fif antibodyAnti-Protein Xagl antibodyAnti-API5 antibodyAnti-MIG8 antibody |
Information sourced from Uniprot.org