| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
APH1B |
| Gene ID: |
83464 |
| Uniprot ID: |
APH1B_HUMAN |
| Immunogen Region: |
100 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human APH1B (NP_112591.2). |
| Immunogen Sequence: |
GLKSINPGETAPSMRLLAYV SGLGFGIMSGVFSFVNTLSD SLGPGTVGIHGDSPQFFLYS AFMTLVIILLHVFWGIVFFD GCEKKKWGILLIVLLTHLLV SAQTFISSYYGINLASAFII LVLMGTWAFLAAGGSCRSLK LCLLCQDKNFLLYNQRSR |
| Tissue Specificity | Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain. |
| Function | Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. |
| Protein Name | Gamma-Secretase Subunit Aph-1bAph-1bAph-1betaPresenilin-Stabilization Factor-Like |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-193692Reactome: R-HSA-205043Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-3928665Reactome: R-HSA-9013507Reactome: R-HSA-9013700Reactome: R-HSA-9017802Reactome: R-HSA-977225Reactome: R-HSA-9839383 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Gamma-Secretase Subunit Aph-1b antibodyAnti-Aph-1b antibodyAnti-Aph-1beta antibodyAnti-Presenilin-Stabilization Factor-Like antibodyAnti-APH1B antibodyAnti-PSFL antibodyAnti-UNQ688 antibodyAnti-PRO1328 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
