| Short Description : | Rabbit monoclonal anti-APC6 for use in WB, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ICC/IF |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | R01-6E7 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | CDC16 |
| Gene ID: | 8881 |
| Uniprot ID: | CDC16_HUMAN |
| Immunogen: | A synthesized peptide derived from human Cdc16/APC6 |
| Post Translational Modifications | Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis. |
| Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. |
| Protein Name | Cell Division Cycle Protein 16 HomologAnaphase-Promoting Complex Subunit 6Apc6Cdc16 HomologCdc16hsCyclosome Subunit 6 |
| Database Links | Reactome: R-HSA-141430Reactome: R-HSA-174048Reactome: R-HSA-174084Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-176407Reactome: R-HSA-176408Reactome: R-HSA-176409Reactome: R-HSA-176412Reactome: R-HSA-179409Reactome: R-HSA-2467813Reactome: R-HSA-2559582Reactome: R-HSA-68867Reactome: R-HSA-69017Reactome: R-HSA-8853884Reactome: R-HSA-9687136Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleColocalizes With Cdc27 To The Centrosome At All Stages Of The Cell Cycle And To The Mitotic Spindle |
| Alternative Antibody Names | Anti-Cell Division Cycle Protein 16 Homolog antibodyAnti-Anaphase-Promoting Complex Subunit 6 antibodyAnti-Apc6 antibodyAnti-Cdc16 Homolog antibodyAnti-Cdc16hs antibodyAnti-Cyclosome Subunit 6 antibodyAnti-CDC16 antibodyAnti-ANAPC6 antibody |
Information sourced from Uniprot.org
