| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human/Rat/Mouse/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-AP-2 gamma (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000. WB: WB experiments gave bands at approx 75kDa and 22kDa in Human Placenta and Ovary lysates after 0.1µg/ml antibody staining. Please note that currently we cannot find an explanation in t |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | TFAP2C |
| Gene ID: | 7022 |
| Uniprot ID: | AP2C_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_003213.1 |
| Immunogen Sequence: | NKTLEKMEKHRK |
| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. |
| Protein Name | Transcription Factor Ap-2 Gamma Ap2-Gamma Activating Enhancer-Binding Protein 2 Gamma Transcription Factor Erf-1 |
| Database Links | Reactome: R-HSA-3232118 Reactome: R-HSA-8866904 Reactome: R-HSA-8866906 Reactome: R-HSA-8866907 Reactome: R-HSA-8866910 Reactome: R-HSA-8866911 Reactome: R-HSA-9827857 Reactome: R-HSA-9834899 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Ap-2 Gamma antibody Anti-Ap2-Gamma antibody Anti-Activating Enhancer-Binding Protein 2 Gamma antibody Anti-Transcription Factor Erf-1 antibody Anti-TFAP2C antibody |
Information sourced from Uniprot.org