Anti-AOX1 antibody (340-590) (STJ22625)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal AOX1 (340-590) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AOX1 |
| Gene ID | 316 |
| Uniprot ID | AOXA_HUMAN |
| Immunogen Region | 340-590 |
| Immunogen Sequence | HLGTLAGSQIRNMASLGGHI ISRHPDSDLNPILAVGNCTL NLLSKEGKRQIPLNEQFLSK CPNADLKPQEILVSVNIPYS RKWEFVSAFRQAQRQENALA IVNSGMRVFFGEGDGIIREL CISYGGVGPATICAKNSCQK LIGRHWNEQMLDIACRLILN EVSLLGSAPGGKVEFKRTLI ISFLFKFYLEVSQILKKMDP VHYPSLADKYESALEDLHSK HHCSTLKYQNIGPKQHPED |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 340-590 of human AOX1 (NP_001150.3). |
Additional Info
| Tissue Specificity | Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level). |
| Function | Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. |
| Protein Name | Aldehyde OxidaseAldehyde Oxidase 1Azaheterocycle Hydroxylase |
| Database Links | Reactome: R-HSA-964975 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Aldehyde Oxidase antibodyAnti-Aldehyde Oxidase 1 antibodyAnti-Azaheterocycle Hydroxylase antibodyAnti-AOX1 antibodyAnti-AO antibody |
Information sourced from Uniprot.org