• Western blot analysis of extracts of various cell lines, using ANTXR1 antibody (STJ28608) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-ANTXR1 antibody (84-333) (STJ28608)

SKU:
STJ28608

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ANTXR1 (84-333) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ANTXR1
Gene ID: 84168
Uniprot ID: ANTR1_HUMAN
Immunogen Region: 84-333
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 84-333 of human ANTXR1 (NP_060623.2).
Immunogen Sequence: VFSTRGTTLMKLTEDREQIR QGLEELQKVLPGGDTYMHEG FERASEQIYYENRQGYRTAS VIIALTDGELHEDLFFYSER EANRSRDLGAIVYCVGVKDF NETQLARIADSKDHVFPVND GFQALQGIIHSILKKSCIEI LAAEPSTICAGESFQVVVRG NGFRHARNVDRVLCSFKIND SVTLNEKPFSVEDTYLLCPA PILKEVGMKAALQVSMNDGL SFISSSVIITTTHCSLHKI
Tissue Specificity Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
Function Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis.
Protein Name Anthrax Toxin Receptor 1
Tumor Endothelial Marker 8
Database Links Reactome: R-HSA-5210891
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Lamellipodium Membrane
Filopodium Membrane
At The Membrane Of Lamellipodia And At The Tip Of Actin-Enriched Filopodia
Colocalizes With Actin At The Base Of Lamellipodia
Alternative Antibody Names Anti-Anthrax Toxin Receptor 1 antibody
Anti-Tumor Endothelial Marker 8 antibody
Anti-ANTXR1 antibody
Anti-ATR antibody
Anti-TEM8 antibody

Information sourced from Uniprot.org

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