• Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TM16J Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of HepG2 cells, using TM16J Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-ANO9 antibody (481-530 aa) (STJ91605)

SKU:
STJ91605

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Anoctamin-9 (481-530 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ANO9
Gene ID: 338440
Uniprot ID: ANO9_HUMAN
Immunogen Region: 481-530 aa
Specificity: Anoctamin-9 Polyclonal Antibody detects endogenous levels of Anoctamin-9 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human TM16J at the amino acid range 481-530
Post Translational Modifications Phosphorylated on serine residues by cAMP-dependent protein kinase A (PKA) which is essential for activation of its cation channel activity.
Function PKA-activated nonselective cation channel. Discriminates poorly among cations but is more permeable to Ca(2+) ions than to monovalent cations. Acts as a calcium-activated calcium permeable channel which may operate as a endoplasmic reticulum (ER) Ca(2+)-leak channel, reducing the loading of the ER Ca(2+) store. Regulates intracellular Ca2+ signals, ion channel activity, and cytokine release in the renal tissue. Plays an important role in olfaction, amplifying cAMP-evoked cyclic nucleotide-gated (CNG) channel currents in the olfactory sensory neurons. Has calcium-dependent phospholipid scramblase activity.scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
Protein Name Anoctamin-9
Transmembrane Protein 16j
Tumor Protein P53-Inducible Protein 5
P53-Induced Gene 5 Protein
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-9733458
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum
Shows Predominantly An Intracellular Localization With A Weak Expression In The Cell Membrane
Alternative Antibody Names Anti-Anoctamin-9 antibody
Anti-Transmembrane Protein 16j antibody
Anti-Tumor Protein P53-Inducible Protein 5 antibody
Anti-P53-Induced Gene 5 Protein antibody
Anti-ANO9 antibody
Anti-PIG5 antibody
Anti-TMEM16J antibody
Anti-TP53I5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance