| Post Translational Modifications | Phosphorylated on serine residues by cAMP-dependent protein kinase A (PKA) which is essential for activation of its cation channel activity. |
| Function | PKA-activated nonselective cation channel. Discriminates poorly among cations but is more permeable to Ca(2+) ions than to monovalent cations. Acts as a calcium-activated calcium permeable channel which may operate as a endoplasmic reticulum (ER) Ca(2+)-leak channel, reducing the loading of the ER Ca(2+) store. Regulates intracellular Ca2+ signals, ion channel activity, and cytokine release in the renal tissue. Plays an important role in olfaction, amplifying cAMP-evoked cyclic nucleotide-gated (CNG) channel currents in the olfactory sensory neurons. Has calcium-dependent phospholipid scramblase activity.scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. |
| Protein Name | Anoctamin-9Transmembrane Protein 16jTumor Protein P53-Inducible Protein 5P53-Induced Gene 5 Protein |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-9733458 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumShows Predominantly An Intracellular Localization With A Weak Expression In The Cell Membrane |
| Alternative Antibody Names | Anti-Anoctamin-9 antibodyAnti-Transmembrane Protein 16j antibodyAnti-Tumor Protein P53-Inducible Protein 5 antibodyAnti-P53-Induced Gene 5 Protein antibodyAnti-ANO9 antibodyAnti-PIG5 antibodyAnti-TMEM16J antibodyAnti-TP53I5 antibody |
Information sourced from Uniprot.org
