Anti-ANKS1B antibody (STJA0009611)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ANKS1B
General Information
| Short Description | Rabbit polyclonal anti-Ankyrin repeat and sterile alpha motif domain-containing protein 1B for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANKS1B |
| Gene ID | 56899 |
| Uniprot ID | ANS1B_HUMAN |
| Immunogen | Synthesized peptide derived from human ANKS1B |
| Specificity | This antibody detects endogenous levels of ANKS1B at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage. |
| Function | Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. |
| Protein Name | Ankyrin Repeat And Sterile Alpha Motif Domain-Containing Protein 1bAmyloid-Beta Protein Intracellular Domain-Associated Protein 1Aida-1E2a-Pbx1-Associated ProteinEb-1 |
| Database Links | |
| Cellular Localisation | CytoplasmIsoform 2: NucleusIsoform 3: Postsynaptic DensityCell ProjectionDendritic SpineNucleusCajal BodyThe Synaptic Localization Requires Dlg4 InteractionTranslocation To The Nucleus In Response To Stimulation Of Nmda Receptors (Nmdars) In A Calcium-Independent MannerIsoform 4: NucleusThe Interaction With App Causes Its Partial Exclusion From The NucleusWhen App Is OverexpressedIsoform 6: Nucleus |
| Alternative Antibody Names | Anti-Ankyrin Repeat And Sterile Alpha Motif Domain-Containing Protein 1b antibodyAnti-Amyloid-Beta Protein Intracellular Domain-Associated Protein 1 antibodyAnti-Aida-1 antibodyAnti-E2a-Pbx1-Associated Protein antibodyAnti-Eb-1 antibodyAnti-ANKS1B antibody |
Information sourced from Uniprot.org