Anti-ANKH antibody (210-320) (STJ111923)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ANKH (210-320) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANKH |
| Gene ID | 56172 |
| Uniprot ID | ANKH_HUMAN |
| Immunogen Region | 210-320 |
| Immunogen Sequence | LGYYKNIHDIIPDRSGPELG GDATIRKMLSFWWPLALILA TQRISRPIVNLFVSRDLGGS SAATEAVAILTATYPVGHMP YGWLTEIRAVYPAFDKNNPS NKLVSTSNTVT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 210-320 of human ANKH (NP_473368.1). |
Additional Info
| Tissue Specificity | Found in osteoblasts from mandibular bone and from iliac bone.not detected in osteoclastic cells. |
| Function | Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength. The transport mechanism remains to be elucidated (Probable). |
| Protein Name | Mineralization Regulator AnkhAtp Carrier Protein AnkhProgressive Ankylosis Protein HomologAnk |
| Database Links | Reactome: R-HSA-5223345 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mineralization Regulator Ankh antibodyAnti-Atp Carrier Protein Ankh antibodyAnti-Progressive Ankylosis Protein Homolog antibodyAnti-Ank antibodyAnti-ANKH antibodyAnti-KIAA1581 antibodyAnti-UNQ241 antibodyAnti-PRO274 antibody |
Information sourced from Uniprot.org