| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ANGPT2 |
| Gene ID: | 285 |
| Uniprot ID: | ANGP2_HUMAN |
| Immunogen Region: | 197-496 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 197-496 of human ANGPT2 (NP_001138.1). |
| Immunogen Sequence: | AMEDKHIIQLQSIKEEKDQL QVLVSKQNSIIEELEKKIVT ATVNNSVLQKQQHDLMETVN NLLTMMSTSNSAKDPTVAKE EQISFRDCAEVFKSGHTTNG IYTLTFPNSTEEIKAYCDME AGGGGWTIIQRREDGSVDFQ RTWKEYKVGFGNPSGEYWLG NEFVSQLTNQQRYVLKIHLK DWEGNEAYSLYEHFYLSSEE LNYRIHLKGLTGTAGKISSI SQPGNDFSTKDGDNDKCIC |
| Function | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis. |
| Protein Name | Angiopoietin-2Ang-2 |
| Database Links | Reactome: R-HSA-210993 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Angiopoietin-2 antibodyAnti-Ang-2 antibodyAnti-ANGPT2 antibody |
Information sourced from Uniprot.org