Anti-Ancient ubiquitous protein 1 antibody (48-60 aa) (STJA0041011)

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STJA0041011-100
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Host: Sheep
Applications: IHC-F/WB
Reactivity: Bovine/Human/Rat/Sheep
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Sheep polyclonal anti-Ancient ubiquitous protein 1 (48-60 aa) for use in IHC-F and WB in Bovine, Human, Rat and Sheep samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: Mixed
Purification: Whole serum
Dilution Range: WB 1:500-1:6000
IHC 1:500-1:6000
Storage Instruction: Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at-20°C for a higher stability, and at 2-8°C with an appropriate antibacterial
Gene Symbol: AUP1
Gene ID: 550
Uniprot ID: AUP1_HUMAN
Immunogen Region: 48-60 aa
Specificity: This antiserum is specific for ancient ubiquitous protein 1. This antibody is known to react with bovine, sheep, human and rat ancient ubiquitous protein 1. Other species have not yet been tested.
Immunogen: A synthetic peptide (HVFLVSCALPDSV) corresponding to the amino acids 48-60 of human ancient ubiquitous protein 1 conjugated to Blue carrier protein has been used as the immunogen. The peptide is homologous with the corresponding sequence derived from
Immunogen Sequence: Human
Tissue Specificity Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.
Post Translational Modifications Monoubiquitinated and diubiquitinated. (Microbial infection) Not ubiquitinated following Dengue virus infection.
Function Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2. Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB. (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles.
Protein Name Lipid Droplet-Regulating Vldl Assembly Factor Aup1
Ancient Ubiquitous Protein 1
Database Links
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Lipid Droplet
Cytoplasmic Vesicle
Autophagosome
(Microbial Infection) Upon Dengue Virus Infection
Relocates From Lipid Droplets To Autophagosomes
Alternative Antibody Names Anti-Lipid Droplet-Regulating Vldl Assembly Factor Aup1 antibody
Anti-Ancient Ubiquitous Protein 1 antibody
Anti-AUP1 antibody

Information sourced from Uniprot.org

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