| Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. APC7 is not required for the assembly of the APC/C complex, but has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates. Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis. |
| Protein Name | Anaphase-Promoting Complex Subunit 7Apc7Cyclosome Subunit 7 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusSpindleLocalizes To Spindle During Metaphase And To Cytoplasmic Microtubules During Interphase |
| Alternative Antibody Names | Anti-Anaphase-Promoting Complex Subunit 7 antibodyAnti-Apc7 antibodyAnti-Cyclosome Subunit 7 antibodyAnti-ANAPC7 antibodyAnti-APC7 antibody |
Information sourced from Uniprot.org
