| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-AMPA1/GLUR1 (264-277) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.1-0.3µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
GRIA1 |
| Gene ID: |
2890 |
| Uniprot ID: |
GRIA1_HUMAN |
| Immunogen Region: |
264-277 |
| Accession Number: |
NP_000818.2; NP_001107655.1 |
| Specificity: |
This antibody is expected to recognize both reported isoforms (NP_000818.2; NP_001107655.1). |
| Immunogen Sequence: |
KIMQQWKNSDARD |
| Post Translational Modifications | Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2. Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation. |
| Function | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Protein Name | Glutamate Receptor 1Glur-1Ampa-Selective Glutamate Receptor 1Glur-AGlur-K1Glutamate Receptor Ionotropic - Ampa 1Glua1 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-399710Reactome: R-HSA-399719Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-5694530Reactome: R-HSA-8849932Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembranePostsynaptic Cell MembranePostsynaptic Density MembraneCell ProjectionDendriteDendritic SpineEarly Endosome MembraneRecycling Endosome MembranePresynapseSynapseInteraction With Cacng2Cnih2 And Cnih3 Promotes Cell Surface ExpressionColocalizes With Pdlim4 In Early EndosomesDisplays A Somatodendritic Localization And Is Excluded From Axons In NeuronsLocalized To Cone Photoreceptor Pedicles |
| Alternative Antibody Names | Anti-Glutamate Receptor 1 antibodyAnti-Glur-1 antibodyAnti-Ampa-Selective Glutamate Receptor 1 antibodyAnti-Glur-A antibodyAnti-Glur-K1 antibodyAnti-Glutamate Receptor Ionotropic - Ampa 1 antibodyAnti-Glua1 antibodyAnti-GRIA1 antibodyAnti-GLUH1 antibodyAnti-GLUR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
