Anti-AMH antibody (Arg26-Arg451) [11303] (STJ400252)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenN-terminal region of AMH within amino acids Arg26-Arg451
General Information
| Short Description | Mouse monoclonal anti-AMH (Arg26-Arg451) for use in LF, CLIA and FIA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | LF/CLIA/FIA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 11303 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 5.0 mg/ml (+/-10 %) |
| Formulation | 50 mM citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative |
| Storage Instruction | Store at 2–8 °C, and do not freeze. |
Target Information
| Immunogen | N-terminal region of AMH within amino acids Arg26-Arg451 |
| Immunogen Region | Arg26-Arg451 |
| Specificity | Antibody recognizes human anti-Müllerian hormone (AMH). Not determined |
Additional Info
| Tissue Specificity | In ovaries, AMH is detected in granulosa cells of early growing follicles. |
| Post Translational Modifications | Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus. |
| Function | Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression. |
| Protein Name | Muellerian-Inhibiting FactorAnti-Muellerian HormoneAmhMuellerian-Inhibiting SubstanceMis |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-9690406 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Muellerian-Inhibiting Factor antibodyAnti-Anti-Muellerian Hormone antibodyAnti-Amh antibodyAnti-Muellerian-Inhibiting Substance antibodyAnti-Mis antibodyAnti-AMH antibodyAnti-MIF antibody |
Information sourced from Uniprot.org