| Tissue Specificity | In ovaries, AMH is detected in granulosa cells of early growing follicles. |
| Post Translational Modifications | Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus. |
| Function | Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression. |
| Protein Name | Muellerian-Inhibiting FactorAnti-Muellerian HormoneAmhMuellerian-Inhibiting SubstanceMis |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-9690406 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Muellerian-Inhibiting Factor antibodyAnti-Anti-Muellerian Hormone antibodyAnti-Amh antibodyAnti-Muellerian-Inhibiting Substance antibodyAnti-Mis antibodyAnti-AMH antibodyAnti-MIF antibody |
Information sourced from Uniprot.org
