| Short Description : | Goat polyclonal antibody anti-ALS2CR2/ILPIP (C-Term) is suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Applications: | Pep-ELISA/WB/IHC/IF |
| Host: | Goat |
| Reactivity: | Human/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 35kDa band observed in Human Heart, Liver and Muscle lysates (calculated MW of 47.0kDa according to NP_061041.2 (alpha isoform) and 31.2kDa according to AAF71042.1 (beta isoform |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | STRADB |
| Gene ID: | 55437 |
| Uniprot ID: | STRAB_HUMAN |
| Accession Number: | NP_061041.2; AAF71042.1 |
| Immunogen Region: | C-Term |
| Immunogen Sequence: | CDFPDEKDSYWEF |
| Specificity: | This is expected to recognise both human isoforms: ILPIP-alpha (NP_061041.2) and ILPIP-beta (AAF71042.1). |
| Function | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. |
| Protein Name | Ste20-Related Kinase Adapter Protein BetaStrad BetaAmyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 ProteinCals-21Ilp-Interacting ProteinPseudokinase Als2cr2 |
| Database Links | Reactome: R-HSA-380972 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Ste20-Related Kinase Adapter Protein Beta antibodyAnti-Strad Beta antibodyAnti-Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein antibodyAnti-Cals-21 antibodyAnti-Ilp-Interacting Protein antibodyAnti-Pseudokinase Als2cr2 antibodyAnti-STRADB antibodyAnti-ALS2CR2 antibodyAnti-ILPIP antibodyAnti-PRO1038 antibody |
Information sourced from Uniprot.org
