| Tissue Specificity | Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue. |
| Function | Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins. |
| Protein Name | Arachidonate 12-Lipoxygenase - 12r-Type12r-Lox12r-LipoxygenaseEpidermis-Type Lipoxygenase 12 |
| Database Links | Reactome: R-HSA-2142712 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Arachidonate 12-Lipoxygenase - 12r-Type antibodyAnti-12r-Lox antibodyAnti-12r-Lipoxygenase antibodyAnti-Epidermis-Type Lipoxygenase 12 antibodyAnti-ALOX12B antibody |
Information sourced from Uniprot.org
