| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ALOX12B |
| Gene ID: | 242 |
| Uniprot ID: | LX12B_HUMAN |
| Immunogen Region: | 1-250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ALOX12B (NP_001130.1). |
| Immunogen Sequence: | MATYKVRVATGTDLLSGTRD SISLTIVGTQGESHKQLLNH FGRDFATGAVGQYTVQCPQD LGELIIIRLHKERYAFFPKD PWYCNYVQICAPNGRIYHFP AYQWMDGYETLALREATGKT TADDSLPVLLEHRKEEIRAK QDFYHWRVFLPGLPSYVHIP SYRPPVRRHRNPNRPEWNGY IPGFPILINFKATKFLNLNL RYSFLKTASFFVRLGPMALA FKVRGLLDCKHSWKRLKDI |
| Tissue Specificity | Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue. |
| Function | Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins. |
| Protein Name | Arachidonate 12-Lipoxygenase - 12r-Type 12r-Lox 12r-Lipoxygenase Epidermis-Type Lipoxygenase 12 |
| Database Links | Reactome: R-HSA-2142712 |
| Cellular Localisation | Cytoplasm Perinuclear Region |
| Alternative Antibody Names | Anti-Arachidonate 12-Lipoxygenase - 12r-Type antibody Anti-12r-Lox antibody Anti-12r-Lipoxygenase antibody Anti-Epidermis-Type Lipoxygenase 12 antibody Anti-ALOX12B antibody |
Information sourced from Uniprot.org