| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ALMS1 (4100-4150 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | ALMS1 |
| Gene ID: | 7840 |
| Uniprot ID: | ALMS1_HUMAN |
| Immunogen Region: | 4100-4150 aa |
| Specificity: | Specific for ALMS1. |
| Immunogen: | A synthetic peptide from aa region 4100-4150 of human ALMS1 conjugated to blue carrier protein was used as the antigen. |
| Function | Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. |
| Protein Name | Centrosome-Associated Protein Alms1Alstrom Syndrome Protein 1 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCilium Basal BodySpindle PoleAssociated With Centrosomes And Basal Bodies At The Base Of Primary CiliaSpecifically Locates To The Proximal Ends Of Centrioles And Basal BodiesColocalizes Partially With Ncapd2 At These SitesDuring Mitosis Localizes To Both Spindle Poles |
| Alternative Antibody Names | Anti-Centrosome-Associated Protein Alms1 antibodyAnti-Alstrom Syndrome Protein 1 antibodyAnti-ALMS1 antibodyAnti-KIAA0328 antibody |
Information sourced from Uniprot.org