| Short Description : | Rabbit polyclonal anti-ALK and LTK ligand 2 (64-114 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ALKAL2 |
| Gene ID: | 285016 |
| Uniprot ID: | ALKL2_HUMAN |
| Immunogen: | Synthesized peptide derived from the human F150B at the amino acid range 64-114 |
| Immunogen Region: | 64-114 aa |
| Specificity: | This antibody detects endogenous levels of F150B at Human/Mouse/Rat |
| Function | Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation. Cytokine-binding is sufficient to activate LTK. In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK. Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure. |
| Protein Name | Alk And Ltk Ligand 2Augmentor AlphaAug-Alpha |
| Database Links | Reactome: R-HSA-201556Reactome: R-HSA-9842663 |
| Cellular Localisation | SecretedCell MembraneFollowing Interaction With Receptor Tyrosine Kinase AlkAssociates With The Cell MembraneMembrane-Binding Is Required To Activate Alk |
| Alternative Antibody Names | Anti-Alk And Ltk Ligand 2 antibodyAnti-Augmentor Alpha antibodyAnti-Aug-Alpha antibodyAnti-ALKAL2 antibodyAnti-FAM150B antibodyAnti-UNQ542 antibodyAnti-PRO1097 antibody |
Information sourced from Uniprot.org
