| Function | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide. Man(5)GlcNAc(2)-PP-dolichol is a substrate for ALG3, the following enzyme in the biosynthetic pathway. |
| Protein Name | Gdp-Man -Man(3glcnac(2-Pp-Dol Alpha-1 -2-MannosyltransferaseAsparagine-Linked Glycosylation Protein 11 HomologGlycolipid 2-Alpha-Mannosyltransferase |
| Database Links | Reactome: R-HSA-446193Reactome: R-HSA-4551295 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Gdp-Man -Man(3glcnac(2-Pp-Dol Alpha-1 -2-Mannosyltransferase antibodyAnti-Asparagine-Linked Glycosylation Protein 11 Homolog antibodyAnti-Glycolipid 2-Alpha-Mannosyltransferase antibodyAnti-ALG11 antibodyAnti-GT8 antibody |
Information sourced from Uniprot.org
