| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ALDOB |
| Gene ID: | 229 |
| Uniprot ID: | ALDOB_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ALDOB (NP_000026.2). |
| Immunogen Sequence: | MAHRFPALTQEQKKELSEIA QSIVANGKGILAADESVGTM GNRLQRIKVENTEENRRQFR EILFSVDSSINQSIGGVILF HETLYQKDSQGKLFRNILKE KGIVVGIKLDQGGAPLAGTN KETTIQGLDGLSERCAQYKK DGVDFGKWRAVLRIADQCPS SLAIQENANALARYASICQQ NGLVPIVEPEVIPDGDHDLE |
| Function | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde. Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check. |
| Protein Name | Fructose-Bisphosphate Aldolase BLiver-Type Aldolase |
| Database Links | Reactome: R-HSA-5657560Reactome: R-HSA-70171Reactome: R-HSA-70263Reactome: R-HSA-70350 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonMicrotubule Organizing CenterCentrosomeCentriolar Satellite |
| Alternative Antibody Names | Anti-Fructose-Bisphosphate Aldolase B antibodyAnti-Liver-Type Aldolase antibodyAnti-ALDOB antibodyAnti-ALDB antibody |
Information sourced from Uniprot.org