| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ALDH4A1 (354-563) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:2000-1:7000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ALDH4A1 |
| Gene ID: |
8659 |
| Uniprot ID: |
AL4A1_HUMAN |
| Immunogen Region: |
354-563 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 354-563 of human ALDH4A1 (NP_003739.2). |
| Immunogen Sequence: |
LYVPHSLWPQIKGRLLEEHS RIKVGDPAEDFGTFFSAVID AKSFARIKKWLEHARSSPSL TILAGGKCDDSVGYFVEPCI VESKDPQEPIMKEEIFGPVL SVYVYPDDKYKETLQLVDST TSYGLTGAVFSQDKDVVQEA TKVLRNAAGNFYINDKSTGS IVGQQPFGGARASGTNDKPG GPHYILRWTSPQVIKETHKP LGDWSYAYMQ |
| Tissue Specificity | Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas. |
| Function | Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. |
| Protein Name | Delta-1-Pyrroline-5-Carboxylate Dehydrogenase - MitochondrialP5c DehydrogenaseAldehyde Dehydrogenase Family 4 Member A1L-Glutamate Gamma-Semialdehyde Dehydrogenase |
| Database Links | Reactome: R-HSA-389661Reactome: R-HSA-70688 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Delta-1-Pyrroline-5-Carboxylate Dehydrogenase - Mitochondrial antibodyAnti-P5c Dehydrogenase antibodyAnti-Aldehyde Dehydrogenase Family 4 Member A1 antibodyAnti-L-Glutamate Gamma-Semialdehyde Dehydrogenase antibodyAnti-ALDH4A1 antibodyAnti-ALDH4 antibodyAnti-P5CDH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
