| Short Description : | Rabbit polyclonal ALDH18A1 (1-240) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ALDH18A1 |
| Gene ID: | 5832 |
| Uniprot ID: | P5CS_HUMAN |
| Immunogen Region: | 1-240 |
| Immunogen Sequence: | MLSQVYRCGFQPFNQHLLPW VKCTTVFRSHCIQPSVIRHV RSWSNIPFITVPLSRTHGKS FAHRSELKHAKRIVVKLGSA VVTRGDECGLALGRLASIVE QVSVLQNQGREMMLVTSGAV AFGKQRLRHEILLSQSVRQA LHSGQNQLKEMAIPVLEARA CAAAGQSGLMALYEAMFTQY SICAAQILVTNLDFHDEQKR RNLNGTLHELLRMNIVPIVN TNDAVVPPAEPNSDLQGVN |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ALDH18A1 (NP_002851.2). |
| Function | Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. |
| Protein Name | Delta-1-Pyrroline-5-Carboxylate SynthaseP5csAldehyde Dehydrogenase Family 18 Member A1 Includes - Glutamate 5-KinaseGkGamma-Glutamyl Kinase - Gamma-Glutamyl Phosphate ReductaseGprGlutamate-5-Semialdehyde DehydrogenaseGlutamyl-Gamma-Semialdehyde Dehydrogenase |
| Database Links | Reactome: R-HSA-8964539Reactome: R-HSA-9837999 |
| Cellular Localisation | MitochondrionMitochondrion MatrixExhibits Puncta-Like Structures Inside Mitochondria Under Nutrient StressWhen Cellular Dependence On Oxidative Phosphorylation IncreasesForms FilamentsWhich May Increase Its ActivityAnd Is Sequestered In A Subset Of Atypical Mitochondria That Lack Cristae And Atp Synthase |
| Alternative Antibody Names | Anti-Delta-1-Pyrroline-5-Carboxylate Synthase antibodyAnti-P5cs antibodyAnti-Aldehyde Dehydrogenase Family 18 Member A1 Includes - Glutamate 5-Kinase antibodyAnti-Gk antibodyAnti-Gamma-Glutamyl Kinase - Gamma-Glutamyl Phosphate Reductase antibodyAnti-Gpr antibodyAnti-Glutamate-5-Semialdehyde Dehydrogenase antibodyAnti-Glutamyl-Gamma-Semialdehyde Dehydrogenase antibodyAnti-ALDH18A1 antibodyAnti-GSAS antibodyAnti-P5CS antibodyAnti-PYCS antibody |
Information sourced from Uniprot.org
