| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | ALB |
| Gene ID: | 213 |
| Uniprot ID: | ALBU_HUMAN |
| Immunogen Region: | 25-609 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-609 of human Albumin/ALB (NP_000468.1). |
| Immunogen Sequence: | DAHKSEVAHRFKDLGEENFK ALVLIAFAQYLQQCPFEDHV KLVNEVTEFAKTCVADESAE NCDKSLHTLFGDKLCTVATL RETYGEMADCCAKQEPERNE CFLQHKDDNPNLPRLVRPEV DVMCTAFHDNEETFLKKYLY EIARRHPYFYAPELLFFAKR YKAAFTECCQAADKAACLLP KLDELRDEGKASSAKQRLKC ASLQKFGERAFKAWAVARLS QRFPKAEFAEVSKLVTDLT |
| Tissue Specificity | Plasma. |
| Post Translational Modifications | Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606. Glycated in diabetic patients. Phosphorylated by FAM20C in the extracellular medium. Acetylated on Lys-223 by acetylsalicylic acid. |
| Function | Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin. |
| Protein Name | Albumin |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-159418 Reactome: R-HSA-189451 Reactome: R-HSA-189483 Reactome: R-HSA-2168880 Reactome: R-HSA-381426 Reactome: R-HSA-8957275 Reactome: R-HSA-8964058 Reactome: R-HSA-9707564 Reactome: R-HSA-9749641 Reactome: R-HSA-9757110 Reactome: R-HSA-9793528 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Albumin antibody Anti-ALB antibody Anti-GIG20 antibody Anti-GIG42 antibody Anti-PRO0903 antibody Anti-PRO1708 antibody Anti-PRO2044 antibody Anti-PRO2619 antibody Anti-PRO2675 antibody Anti-UNQ696 antibody Anti-PRO1341 antibody |
Information sourced from Uniprot.org