| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Aldo-keto reductase family 1 member D1-3-ketosteroid 5-beta-reductase-3-oxosteroid 5-beta-reductase (258-308 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AKR1D1 |
| Gene ID: | 6718 |
| Uniprot ID: | AK1D1_HUMAN |
| Immunogen Region: | 258-308 aa |
| Specificity: | This antibody detects endogenous levels of AK1D1 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human AK1D1 at the amino acid range 258-308 |
| Function | Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one). |
| Protein Name | Aldo-Keto Reductase Family 1 Member D13-Oxo-5-Beta-Steroid 4-DehydrogenaseDelta(4-3-Ketosteroid 5-Beta-ReductaseDelta(4-3-Oxosteroid 5-Beta-Reductase |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-193807 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member D1 antibodyAnti-3-Oxo-5-Beta-Steroid 4-Dehydrogenase antibodyAnti-Delta(4-3-Ketosteroid 5-Beta-Reductase antibodyAnti-Delta(4-3-Oxosteroid 5-Beta-Reductase antibodyAnti-AKR1D1 antibodyAnti-SRD5B1 antibody |
Information sourced from Uniprot.org
