| Function | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids. |
| Protein Name | Aldo-Keto Reductase Family 1 Member C1 20-Alpha-Hydroxysteroid Dehydrogenase20-Alpha-HsdChlordecone Reductase Homolog HakrcDihydrodiol Dehydrogenase 1Dd1High-Affinity Hepatic Bile Acid-Binding ProteinHbab |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-193807Reactome: R-HSA-975634Reactome: R-HSA-9757110 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member C1 antibodyAnti-20-Alpha-Hydroxysteroid Dehydrogenase antibodyAnti-20-Alpha-Hsd antibodyAnti-Chlordecone Reductase Homolog Hakrc antibodyAnti-Dihydrodiol Dehydrogenase 1 antibodyAnti-Dd1 antibodyAnti-High-Affinity Hepatic Bile Acid-Binding Protein antibodyAnti-Hbab antibodyAnti-AKR1C1 antibodyAnti-DDH antibodyAnti-DDH1 antibody |
Information sourced from Uniprot.org
