Anti-AKR1C1 antibody (30-110 aa) (STJ92669)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from DD1 at the amino acid range 30-110
General Information
| Short Description | Rabbit polyclonal anti-Aldo-keto reductase family 1 member C1 (30-110 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AKR1C1 |
| Gene ID | 1645 |
| Uniprot ID | AK1C1_HUMAN |
| Immunogen | Synthesized peptide derived from DD1 at the amino acid range 30-110 |
| Immunogen Region | 30-110 aa |
| Specificity | DD1 Polyclonal Antibody detects endogenous levels of DD1 protein. |
Additional Info
| Function | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids. |
| Protein Name | Aldo-Keto Reductase Family 1 Member C1 20-Alpha-Hydroxysteroid Dehydrogenase20-Alpha-HsdChlordecone Reductase Homolog HakrcDihydrodiol Dehydrogenase 1Dd1High-Affinity Hepatic Bile Acid-Binding ProteinHbab |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-193807Reactome: R-HSA-975634Reactome: R-HSA-9757110 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member C1 antibodyAnti-20-Alpha-Hydroxysteroid Dehydrogenase antibodyAnti-20-Alpha-Hsd antibodyAnti-Chlordecone Reductase Homolog Hakrc antibodyAnti-Dihydrodiol Dehydrogenase 1 antibodyAnti-Dd1 antibodyAnti-High-Affinity Hepatic Bile Acid-Binding Protein antibodyAnti-Hbab antibodyAnti-AKR1C1 antibodyAnti-DDH antibodyAnti-DDH1 antibody |
Information sourced from Uniprot.org