| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Aldo-keto reductase family 1 member C1 (30-110 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AKR1C1 |
| Gene ID: |
1645 |
| Uniprot ID: |
AK1C1_HUMAN |
| Immunogen Region: |
30-110 aa |
| Specificity: |
DD1 Polyclonal Antibody detects endogenous levels of DD1 protein. |
| Immunogen: |
Synthesized peptide derived from DD1 at the amino acid range 30-110 |
| Function | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids. |
| Protein Name | Aldo-Keto Reductase Family 1 Member C1 20-Alpha-Hydroxysteroid Dehydrogenase20-Alpha-HsdChlordecone Reductase Homolog HakrcDihydrodiol Dehydrogenase 1Dd1High-Affinity Hepatic Bile Acid-Binding ProteinHbab |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-193807Reactome: R-HSA-975634Reactome: R-HSA-9757110 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member C1 antibodyAnti-20-Alpha-Hydroxysteroid Dehydrogenase antibodyAnti-20-Alpha-Hsd antibodyAnti-Chlordecone Reductase Homolog Hakrc antibodyAnti-Dihydrodiol Dehydrogenase 1 antibodyAnti-Dd1 antibodyAnti-High-Affinity Hepatic Bile Acid-Binding Protein antibodyAnti-Hbab antibodyAnti-AKR1C1 antibodyAnti-DDH antibodyAnti-DDH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
