| Tissue Specificity | Found in many tissues. Highly expressed in small intestine, colon and adrenal gland. |
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose. |
| Protein Name | Aldo-Keto Reductase Family 1 Member B10Arl-1Aldose Reductase-LikeAldose Reductase-Related ProteinArpHarpSmall Intestine ReductaseSi Reductase |
| Database Links | Reactome: R-HSA-975634 |
| Cellular Localisation | LysosomeSecretedSecreted Through A Lysosome-Mediated Non-Classical Pathway |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member B10 antibodyAnti-Arl-1 antibodyAnti-Aldose Reductase-Like antibodyAnti-Aldose Reductase-Related Protein antibodyAnti-Arp antibodyAnti-Harp antibodyAnti-Small Intestine Reductase antibodyAnti-Si Reductase antibodyAnti-AKR1B10 antibodyAnti-AKR1B11 antibody |
Information sourced from Uniprot.org
