| Short Description : | Rabbit polyclonal AKR1B10 (1-316) antibody for use in WB, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IP/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AKR1B10 |
| Gene ID: | 57016 |
| Uniprot ID: | AK1BA_HUMAN |
| Immunogen Region: | 1-316 |
| Immunogen Sequence: | MATFVELSTKAKMPIVGLGT WKSPLGKVKEAVKVAIDAGY RHIDCAYVYQNEHEVGEAIQ EKIQEKAVKREDLFIVSKLW PTFFERPLVRKAFEKTLKDL KLSYLDVYLIHWPQGFKSGD DLFPKDDKGNAIGGKATFLD AWEAMEELVDEGLVKALGVS NFSHFQIEKLLNKPGLKYKP VTNQVECHPYLTQEKLIQYC HSKGITVTAYSPLGSPDRPW AKPEDPSLLEDPKIKEIAA |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human AKR1B10 (NP_064695.3). |
| Tissue Specificity | Found in many tissues. Highly expressed in small intestine, colon and adrenal gland. |
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose. |
| Protein Name | Aldo-Keto Reductase Family 1 Member B10Arl-1Aldose Reductase-LikeAldose Reductase-Related ProteinArpHarpSmall Intestine ReductaseSi Reductase |
| Database Links | Reactome: R-HSA-975634 |
| Cellular Localisation | LysosomeSecretedSecreted Through A Lysosome-Mediated Non-Classical Pathway |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member B10 antibodyAnti-Arl-1 antibodyAnti-Aldose Reductase-Like antibodyAnti-Aldose Reductase-Related Protein antibodyAnti-Arp antibodyAnti-Harp antibodyAnti-Small Intestine Reductase antibodyAnti-Si Reductase antibodyAnti-AKR1B10 antibodyAnti-AKR1B11 antibody |
Information sourced from Uniprot.org
