| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AKAP6 |
| Gene ID: | 9472 |
| Uniprot ID: | AKAP6_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human AKAP6 (NP_004265.3). |
| Immunogen Sequence: | MLTMSVTLSPLRSQDLDPMA TDASPMAINMTPTVEQGEGE EAMKDMDSDQQYEKPPPLHT GADWKIVLHLPEIETWLRMT SERVRDLTYSVQQDSDSKHV DVHLVQLKDICEDISDHVEQ IHALLETEFSLKLLSYSVNV IVDIHAVQLLWHQLRVSVLV LRERILQGLQDANGNYTRQT DILQAFSEETKEGRLDSLTE VDDSGQLTIKCSQNYLSLDC GITAFELSDYSPSEDLLSG |
| Tissue Specificity | Highly expressed in cardiac and skeletal muscle, followed by brain. |
| Function | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
| Protein Name | A-Kinase Anchor Protein 6Akap-6A-Kinase Anchor Protein 100 KdaAkap 100Protein Kinase A-Anchoring Protein 6Prka6Makap |
| Cellular Localisation | Sarcoplasmic ReticulumNucleus MembraneIn Heart MuscleParticipation Of Multiple Targeting Signals Allow Correct Intracellular TargetingThese May Be Repeated Motifs Rich In Basic And Hydrophobic Amino AcidsPalmitoylated/Myristoylated Motifs Or Alternatively Splice Targeting Sequences |
| Alternative Antibody Names | Anti-A-Kinase Anchor Protein 6 antibodyAnti-Akap-6 antibodyAnti-A-Kinase Anchor Protein 100 Kda antibodyAnti-Akap 100 antibodyAnti-Protein Kinase A-Anchoring Protein 6 antibodyAnti-Prka6 antibodyAnti-Makap antibodyAnti-AKAP6 antibodyAnti-AKAP100 antibodyAnti-KIAA0311 antibody |
Information sourced from Uniprot.org