| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AKAP5 (1-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AKAP5 |
| Gene ID: |
9495 |
| Uniprot ID: |
AKAP5_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human AKAP5 (NP_004848.3). |
| Immunogen Sequence: |
METTISEIHVENKDEKRSAE GSPGAERQKEKASMLCFKRR KKAAKALKPKAGSEAADVAR KCPQEAGASDQPEPTRGAWA SLKRLVTRRKRSESSKQQKP LEGEMQPAINAEDADLSKKK AKSRLKIPCIKFPRGPKRSN HSKIIEDSDCSIKVQEEAEI LDIQTQTPLNDQATKAKSTQ DLSEGISRKDGDEVCESNVS NSTTSGEKVISVELGLDNGH SAIQTGTLILEEIETIKEK |
| Tissue Specificity | Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary. |
| Post Translational Modifications | Palmitoylated. Palmitoylation at Cys-36 and Cys-129 play a key role in the targeting of AKAP5 to lipid rafts. Palmitoylation by ZDHHC2 is required for AKAP5 function in LTP-stimulated recycling endosome exocytosis. |
| Function | Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses. |
| Protein Name | A-Kinase Anchor Protein 5Akap-5A-Kinase Anchor Protein 79 KdaAkap 79H21Camp-Dependent Protein Kinase Regulatory Subunit Ii High Affinity-Binding Protein |
| Database Links | Reactome: R-HSA-381676Reactome: R-HSA-399719Reactome: R-HSA-9010642 |
| Cellular Localisation | Postsynaptic Recycling Endosome MembraneLipid-AnchorAssociates With Lipid Rafts |
| Alternative Antibody Names | Anti-A-Kinase Anchor Protein 5 antibodyAnti-Akap-5 antibodyAnti-A-Kinase Anchor Protein 79 Kda antibodyAnti-Akap 79 antibodyAnti-H21 antibodyAnti-Camp-Dependent Protein Kinase Regulatory Subunit Ii High Affinity-Binding Protein antibodyAnti-AKAP5 antibodyAnti-AKAP79 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
