| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-A-kinase anchor protein 13 (721-770 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AKAP13 |
| Gene ID: |
11214 |
| Uniprot ID: |
AKP13_HUMAN |
| Immunogen Region: |
721-770 aa |
| Specificity: |
AKAP 13 Polyclonal Antibody detects endogenous levels of AKAP 13 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human AKAP13 at the amino acid range 721-770 |
| Function | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members. Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity. Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1. Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2. Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3. Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy. Has no guanine nucleotide exchange activity on CDC42, Ras or Rac. Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes. Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol. Required for normal adaptive cardiac hypertrophy in response to pressure overload. Plays a role in osteogenesis. |
| Protein Name | A-Kinase Anchor Protein 13Akap-13Akap-LbcBreast Cancer Nuclear Receptor-Binding Auxiliary ProteinGuanine Nucleotide Exchange Factor LbcHuman Thyroid-Anchoring Protein 31Lymphoid Blast Crisis OncogeneLbc OncogeneNon-Oncogenic Rho Gtpase-Specific Gtp Exchange FactorProtein Kinase A-Anchoring Protein 13Prka13P47 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | CytoplasmCytosolCell CortexNucleusMembranePeripheral Membrane ProteinColocalizes With The Actin Cytoskeleton At The Cell Cortex |
| Alternative Antibody Names | Anti-A-Kinase Anchor Protein 13 antibodyAnti-Akap-13 antibodyAnti-Akap-Lbc antibodyAnti-Breast Cancer Nuclear Receptor-Binding Auxiliary Protein antibodyAnti-Guanine Nucleotide Exchange Factor Lbc antibodyAnti-Human Thyroid-Anchoring Protein 31 antibodyAnti-Lymphoid Blast Crisis Oncogene antibodyAnti-Lbc Oncogene antibodyAnti-Non-Oncogenic Rho Gtpase-Specific Gtp Exchange Factor antibodyAnti-Protein Kinase A-Anchoring Protein 13 antibodyAnti-Prka13 antibodyAnti-P47 antibodyAnti-AKAP13 antibodyAnti-BRX antibodyAnti-HT31 antibodyAnti-LBC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
