Anti-AIP1/MAGI2 antibody (C-Term) (STJ70473)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-AIP1/MAGI2 (C-Term) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Preliminary experiments in human brain lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any feedback from people in the f |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | MAGI2 |
| Gene ID | 9863 |
| Uniprot ID | MAGI2_HUMAN |
| Accession Number | NP_036433.2 |
| Immunogen Region | C-Term |
| Immunogen Sequence | PSVLKPGASAASR |
Additional Info
| Function | Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis. |
| Protein Name | Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 2Atrophin-1-Interacting Protein 1Aip-1Atrophin-1-Interacting Protein AMembrane-Associated Guanylate Kinase Inverted 2Magi-2 |
| Database Links | Reactome: R-HSA-373753 |
| Cellular Localisation | CytoplasmLate EndosomeSynapseSynaptosomeCell MembranePeripheral Membrane ProteinCytoskeletonMicrotubule Organizing CenterCentrosomeCell ProjectionCiliumCentriolePhotoreceptor Inner SegmentPhotoreceptor Outer SegmentLocalized Diffusely In The Cytoplasm Before Nerve Growth Factor (Ngf) StimulationRecruited To Late Endosomes After Ngf StimulationMembrane-Associated In Synaptosomes |
| Alternative Antibody Names | Anti-Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 2 antibodyAnti-Atrophin-1-Interacting Protein 1 antibodyAnti-Aip-1 antibodyAnti-Atrophin-1-Interacting Protein A antibodyAnti-Membrane-Associated Guanylate Kinase Inverted 2 antibodyAnti-Magi-2 antibodyAnti-MAGI2 antibodyAnti-ACVRINP1 antibodyAnti-AIP1 antibodyAnti-KIAA0705 antibody |
Information sourced from Uniprot.org