| Post Translational Modifications | N-myristoylation at Gly-2 mediates the recruitment to lipid droplets and plasma membrane. |
| Function | A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms. Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death. Capable of DNA binding in a non-sequence specific way. |
| Protein Name | Ferroptosis Suppressor Protein 1Fsp1Apoptosis-Inducing Factor Homologous Mitochondrion-Associated Inducer Of DeathAmidP53-Responsive Gene 3 Protein |
| Database Links | Reactome: R-HSA-6803204 |
| Cellular Localisation | Lipid DropletCell MembraneLipid-AnchorCytoplasmMitochondrion MembraneNucleus |
| Alternative Antibody Names | Anti-Ferroptosis Suppressor Protein 1 antibodyAnti-Fsp1 antibodyAnti-Apoptosis-Inducing Factor Homologous Mitochondrion-Associated Inducer Of Death antibodyAnti-Amid antibodyAnti-P53-Responsive Gene 3 Protein antibodyAnti-AIFM2 antibodyAnti-AMID antibodyAnti-PRG3 antibody |
Information sourced from Uniprot.org
