| Host: | Rabbit |
| Applications: | IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AIF1 |
| Gene ID: | 199 |
| Uniprot ID: | AIF1_HUMAN |
| Immunogen Region: | 1-147 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human AIF1/IBA1 (P55008). |
| Immunogen Sequence: | MSQTRDLQGGKAFGLLKAQQ EERLDEINKQFLDDPKYSSD EDLPSKLEGFKEKYMEFDLN GNGDIDIMSLKRMLEKLGVP KTHLELKKLIGEVSSGSGET FSYPDFLRMMLGKRSAILKM ILMYEEKAREKEKPTGPPAK KAISELP |
| Tissue Specificity | Detected in T-lymphocytes and peripheral blood mononuclear cells. |
| Post Translational Modifications | Phosphorylated on serine residues. |
| Function | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
| Protein Name | Allograft Inflammatory Factor 1 Aif-1 Ionized Calcium-Binding Adapter Molecule 1 Protein G1 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Projection Ruffle Membrane Peripheral Membrane Protein Cytoplasmic Side Phagocytic Cup Associated With The Actin Cytoskeleton At Membrane Ruffles And At Sites Of Phagocytosis |
| Alternative Antibody Names | Anti-Allograft Inflammatory Factor 1 antibody Anti-Aif-1 antibody Anti-Ionized Calcium-Binding Adapter Molecule 1 antibody Anti-Protein G1 antibody Anti-AIF1 antibody Anti-G1 antibody Anti-IBA1 antibody |
Information sourced from Uniprot.org