| Post Translational Modifications | C-terminal Ser or Thr residues may be phosphorylated. |
| Function | Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. |
| Protein Name | Type-1 Angiotensin Ii ReceptorAt1arAt1brAngiotensin Ii Type-1 ReceptorAt1 Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Type-1 Angiotensin Ii Receptor nanobodyAnti-At1ar nanobodyAnti-At1br nanobodyAnti-Angiotensin Ii Type-1 Receptor nanobodyAnti-At1 Receptor nanobodyAnti-AGTR1 nanobodyAnti-AGTR1A nanobodyAnti-AGTR1B nanobodyAnti-AT2R1 nanobodyAnti-AT2R1B nanobody |
Information sourced from Uniprot.org
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