| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-AF4/FMR2 family member 4 (30-110 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AFF4 |
| Gene ID: | 27125 |
| Uniprot ID: | AFF4_HUMAN |
| Immunogen Region: | 30-110 aa |
| Specificity: | AFF4 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 30-110 |
| Function | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. |
| Protein Name | Af4/Fmr2 Family Member 4 All1-Fused Gene From Chromosome 5q31 Protein Protein Af-5q31 Major Cdk9 Elongation Factor-Associated Protein |
| Database Links | Reactome: R-HSA-112382 Reactome: R-HSA-674695 Reactome: R-HSA-75955 |
| Cellular Localisation | Nucleus Associates To Transcriptionally Active Chromatin But Not At Snrna Genes |
| Alternative Antibody Names | Anti-Af4/Fmr2 Family Member 4 antibody Anti-All1-Fused Gene From Chromosome 5q31 Protein antibody Anti-Protein Af-5q31 antibody Anti-Major Cdk9 Elongation Factor-Associated Protein antibody Anti-AFF4 antibody Anti-AF5Q31 antibody Anti-MCEF antibody Anti-HSPC092 antibody |
Information sourced from Uniprot.org